Complete Clustering results for network physical and phenotype abnormal vermis (FDR <= 0.001)

Setp-ValueGene CountInteraction CountExpected Interection Count
NUCLEUS
(c5) Genes annotated by the GO term GO:0005634. A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1e-201255/1417298199.45
module_98
(c4) Genes in module_98
3.55271e-15366/39113575.173
G1_TO_S_CELL_CYCLE_REACTOME
(c2)
2.77556e-1465/665321.07
CELL_CYCLE_KEGG
(c2)
4.35763e-1380/847134.017
NUCLEAR_PART
(c5) Genes annotated by the GO term GO:0044428. Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.
1.18539e-12509/57214181.679
module_198
(c4) Genes in module_198
1.18894e-12284/30111362.442
CELL_CYCLE
(c2) The progression of biochemical and morphological events that occur during nuclear or cellular replication.
2.48646e-1273/766630.947
HSA04115_P53_SIGNALING_PATHWAY
(c2) Genes involved in p53 signaling pathway
2.62435e-1259/665121.546
RNA_BIOSYNTHETIC_PROCESS
(c5) Genes annotated by the GO term GO:0032774. The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers.
7.68274e-12586/636171108.53
SA_REG_CASCADE_OF_CYCLIN_EXPR
(c2) Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
7.72415e-1212/13226.294
TRANSCRIPTION__DNA_DEPENDENT
(c5) Genes annotated by the GO term GO:0006351. The synthesis of RNA on a template of DNA.
1.58036e-11584/634170108.516
CELLCYCLEPATHWAY
(c2) Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.
2.58608e-1122/233010.546
DNA_METABOLIC_PROCESS
(c5) Genes annotated by the GO term GO:0006259. The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
5.44297e-11236/2568141.632
NUCLEOBASE__NUCLEOSIDE__NUCLEOTIDE_AND_NUCLEIC_ACID_METABOLIC_PROCESS
(c5) Genes annotated by the GO term GO:0006139. The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
7.46454e-111112/1234251175.641
NUCLEAR_PORE
(c5) Genes annotated by the GO term GO:0005643. Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
7.92446e-1130/31174.219
TRANSCRIPTION
(c5) Genes annotated by the GO term GO:0006350. The synthesis of either RNA on a template of DNA or DNA on a template of RNA.
9.27295e-11692/750198133.788
module_197
(c4) Genes in module_197
3.02505e-10152/1736935.521
TRANSCRIPTION_INITIATION
(c5) Genes annotated by the GO term GO:0006352. Processes involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template resulting in the subsequent synthesis of RNA from that promoter.
4.21008e-1034/35195.417
module_57
(c4) Genes in module_57
4.50425e-1054/565023.452
module_252
(c4) Genes in module_252
4.60753e-10221/2359151.526
TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER
(c5) Genes annotated by the GO term GO:0006366. The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
4.70026e-10425/45612980.728
HSA05218_MELANOMA
(c2) Genes involved in melanoma
5.41642e-1064/716130.75
HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT
(c2) Genes involved in SNARE interactions in vesicular transport
5.62201e-1030/36143.192
module_124
(c4) Genes in module_124
9.33538e-1091/964017.012
PORE_COMPLEX
(c5) Genes annotated by the GO term GO:0046930. Any small opening in a membrane that allows the passage of gases and/or liquids.
2.23706e-0935/36184.96
CELL_PROLIFERATION_GO_0008283
(c5) Genes annotated by the GO term GO:0008283. The multiplication or reproduction of cells, resulting in the expansion of a cell population.
3.02629e-09464/51312578.31
NUCLEAR_ENVELOPE
(c5) Genes annotated by the GO term GO:0005635. The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
4.93463e-0966/732911.087
CELL_CYCLE_GO_0007049
(c5) Genes annotated by the GO term GO:0007049. The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
5.0588e-09293/3119252.937
BRENTANI_CELL_CYCLE
(c2) Cancer related genes involved in the cell cycle
5.4411e-0978/795023.556
chr13q32
(c1) Genes in cytogenetic band chr13q32
1.37029e-0812/3040.433
SARCOMAS_SYNOVIAL_UP
(c2) Top 20 positive significant genes associated with synovial sarcomas, versus other soft-tissue tumors.
1.50129e-088/1230.242
RESPONSE_TO_DNA_DAMAGE_STIMULUS
(c5) Genes annotated by the GO term GO:0006974. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
3.5691e-08150/1615527.761
BIOPOLYMER_METABOLIC_PROCESS
(c5) Genes annotated by the GO term GO:0043283. The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.
4.02113e-081493/1667307239.358
ORGANELLE_ENVELOPE
(c5) Genes annotated by the GO term GO:0031967. A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.
4.20331e-08126/1683716.705
ENVELOPE
(c5) Genes annotated by the GO term GO:0031975. A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer, also includes the space between layers.
4.20331e-08126/1683716.705
PROTEIN_DNA_COMPLEX_ASSEMBLY
(c5) Genes annotated by the GO term GO:0065004. The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex.
4.35904e-0845/49227.69
REGULATION_OF_NUCLEOBASE__NUCLEOSIDE__NUCLEOTIDE_AND_NUCLEIC_ACID_METABOLIC_PROCESS
(c5) Genes annotated by the GO term GO:0019219. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
6.45584e-08560/614161111.975
TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER
(c5) Genes annotated by the GO term GO:0006367. Processes involved in starting transcription from the RNA polymerase II promoter.
1.04757e-0728/29165.058
HSA04110_CELL_CYCLE
(c2) Genes involved in cell cycle
1.12146e-07109/1128048.243
GNF2_PCNA
(c4) Neighborhood of PCNA
1.3361e-0758/65249.174
LE_MYELIN_UP
(c2) Genes upregulated in Egr2Lo/Lo mice (who bear mutations in the transcription factor Egr2 and in which peripheral nerve myelination is disrupted) whose expression is significantly altered after sciatic nerve injury.
1.40004e-0773/872811.309
RNA_METABOLIC_PROCESS
(c5) Genes annotated by the GO term GO:0016070. The chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
1.40492e-07760/835174122.808
REGULATION_OF_TRANSCRIPTION
(c5) Genes annotated by the GO term GO:0045449. Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
2.44389e-07514/563149103.975
NEGATIVE_REGULATION_OF_CELLULAR_PROCESS
(c5) Genes annotated by the GO term GO:0048523. Any process that stops, prevents or reduces the frequency, rate or extent of cellular processes, those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
2.49284e-07581/640164118.155
NUCLEAR_LUMEN
(c5) Genes annotated by the GO term GO:0031981. The volume enclosed by the nuclear inner membrane.
2.61274e-07338/3819559.103
NUCLEAR_MEMBRANE_PART
(c5) Genes annotated by the GO term GO:0044453. Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells.
3.197e-0739/42175.669
PROLIFERATION_GENES
(c2) Proliferation related genes
4.06117e-07333/3599661.362
BREASTCA_TWO_CLASSES
(c2) Gene set that can be used to differentiate BRCA1-linked and BRCA2-linked breast cancers
4.35044e-07118/1325631.341
NEGATIVE_REGULATION_OF_BIOLOGICAL_PROCESS
(c5) Genes annotated by the GO term GO:0048519. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
4.45085e-07609/670168122.392
REGULATION_OF_TRANSCRIPTION__DNA_DEPENDENT
(c5) Genes annotated by the GO term GO:0006355. Any process that modulates the frequency, rate or extent of DNA-dependent transcription.
4.82635e-07417/45911979.899
GNF2_CENPF
(c4) Neighborhood of CENPF
5.10289e-0752/58217.913
LAMB_CYCLIN_D3_GLOCUS
(c2) E2F target genes highly correlated with cyclin D3 expression (p = 0.002)
5.27432e-0713/15102.711
REGULATION_OF_RNA_METABOLIC_PROCESS
(c5) Genes annotated by the GO term GO:0051252. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
6.83705e-07425/46812081.048
REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER
(c5) Genes annotated by the GO term GO:0006357. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
7.40061e-07262/2888352.159
ZHAN_MULTIPLE_MYELOMA_VS_NORMAL_UP
(c2) The 70 most significantly up-regulated genes in MM in comparison with normal bone marrow PCs
8.26195e-0749/60228.839
V$E2F1_Q4_01
(c3) Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TTTSGCGSG which matches annotation for E2F
TFDP1: transcription factor Dp-1
9.14868e-07133/1724624.588
V$E2F_01
(c3) Genes with promoter regions [-2kb,2kb] around transcription start site containing motif TWSGCGCGAAAAYKR. Motif does not match any known transcription factor
1.0926e-0646/57228.924
NUCLEAR_MEMBRANE
(c5) Genes annotated by the GO term GO:0031965. Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1.35824e-0645/50197.187
RESPONSE_TO_ENDOGENOUS_STIMULUS
(c5) Genes annotated by the GO term GO:0009719. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endogenous stimulus.
1.70901e-06184/1985731.767
V$E2F_Q3_01
(c3) Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TTTSGCGSG which matches annotation for E2F
TFDP1: transcription factor Dp-1
1.78212e-06134/1764725.404
DNA_REPAIR
(c5) Genes annotated by the GO term GO:0006281. The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
1.81622e-06117/1254221.686
PARP_KO_DN
(c2) Downregulated in MEF cells from PARP knockout mice
1.83985e-0611/14102.638
module_403
(c4) Genes in module_403
1.90367e-0641/462712.211
GNF2_CDC2
(c4) Neighborhood of CDC2
2.11448e-0652/58197.487
DNA_BINDING
(c5) Genes annotated by the GO term GO:0003677. Interacting selectively with DNA (deoxyribonucleic acid).
2.20264e-06513/60013797.176
P53_SIGNALING
(c2) Genes involved in p53 signaling
2.26119e-0686/917749.285
VERNELL_PRB_CLSTR1
(c2) pRB pathway target genes CLUSTER 1 The listed genes were found regulated by pRB and p16 and one of the E2Fs (E2F1, E2F2, or E2F3) Cluster 1 genes are up-regulated by E2F and down-regulated by pRB and p16
2.57682e-0650/61207.89
MEMBRANE_ENCLOSED_LUMEN
(c5) Genes annotated by the GO term GO:0031974. The enclosed volume within a sealed membrane or between two sealed membranes.
2.73949e-06376/4519662.594
ORGANELLE_LUMEN
(c5) Genes annotated by the GO term GO:0043233. The volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear membrane lumen.
2.73949e-06376/4519662.594
module_154
(c4) Genes in module_154
3.07659e-0656/75175.974
GNF2_RRM1
(c4) Neighborhood of RRM1
3.08506e-0676/852510.774
LATE_ENDOSOME
(c5) Genes annotated by the GO term GO:0005770. A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
3.31073e-0611/1261.213
HSA00130_UBIQUINONE_BIOSYNTHESIS
(c2) Genes involved in ubiquinone biosynthesis
3.38959e-063/810.047
NUCLEOLUS
(c5) Genes annotated by the GO term GO:0005730. A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
3.50704e-06101/1233316.463
module_18
(c4) Genes in module_18
3.6208e-06376/4478655.714
TARTE_PLASMA_BLASTIC
(c2) Genes overexpressed in mature plasma cells isolated from tonsils (TPCs) and mature plasma cells isolated from bone marrow (BMPCs) as compared to polyclonal plasmablastic cells (PPCs).
3.9617e-06251/2866438.745
NEGATIVE_REGULATION_OF_NUCLEOBASE__NUCLEOSIDE__NUCLEOTIDE_AND_NUCLEIC_ACID_METABOLIC_PROCESS
(c5) Genes annotated by the GO term GO:0045934. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
4.09652e-06190/2096943.217
GREENBAUM_E2A_UP
(c2) Table includes transcripts up-regulated 3-fold or greater in the E2A-deficient cell lines
4.61725e-0631/33123.723
GNF2_H2AFX
(c4) Neighborhood of H2AFX
4.66358e-0625/30155.475
REGULATION_OF_CELL_PROLIFERATION
(c5) Genes annotated by the GO term GO:0042127. Any process that modulates the frequency, rate or extent of cell proliferation.
5.03648e-06278/3087949.953
REGULATION_OF_CELL_CYCLE
(c5) Genes annotated by the GO term GO:0051726. Any process that modulates the rate or extent of progression through the cell cycle.
5.26046e-06170/1805935.01
NEGATIVE_REGULATION_OF_CELL_PROLIFERATION
(c5) Genes annotated by the GO term GO:0008285. Any process that stops, prevents or reduces the rate or extent of cell proliferation.
5.36731e-06137/1564121.526
INTEGRIN_COMPLEX
(c5) Genes annotated by the GO term GO:0008305. Any member of a family of heterodimeric transmembrane receptors for cell-adhesion molecules. The alpha and beta subunits are noncovalently bonded.
5.52352e-0618/1982.031
module_54
(c4) Genes in module_54
5.93237e-06204/2554625.336
V$E2F1_Q6
(c3) Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif TTTSGCGS which matches annotation for E2F1: E2F transcription factor 1
6.02673e-06141/1744524.426
REGULATION_OF_METABOLIC_PROCESS
(c5) Genes annotated by the GO term GO:0019222. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
6.08728e-06724/794188143.235
G1PATHWAY
(c2) CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.
6.12187e-0625/263216.011
module_349
(c4) Genes in module_349
6.67274e-0610/1730.384
REGULATION_OF_CELLULAR_METABOLIC_PROCESS
(c5) Genes annotated by the GO term GO:0031323. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
6.80587e-06712/782185140.648
SGCGSSAAA_V$E2F1DP2_01
(c3) Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif SGCGSSAAA which matches annotation for E2F1: E2F transcription factor 1
TFDP1: transcription factor Dp-1
RB1: retinoblastoma 1 (including osteosarcoma)
7.85974e-06100/1273215.74
HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS
(c2) Genes involved in heparan sulfate biosynthesis
8.10571e-063/1910.049
SKP2E2FPATHWAY
(c2) E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.
8.24677e-068/9134.689
NUCLEOPLASM
(c5) Genes annotated by the GO term GO:0005654. That part of the nuclear content other than the chromosomes or the nucleolus.
9.25839e-06254/2767950.75
V$E2F_03
(c3) Genes with promoter regions [-2kb,2kb] around transcription start site containing motif TTTSGCGCGMNR. Motif does not match any known transcription factor
9.49317e-06136/1763920.501
TRANSCRIPTION_REPRESSOR_ACTIVITY
(c5) Genes annotated by the GO term GO:0016564. Any transcription regulator activity that prevents or downregulates transcription.
1.01607e-05142/1504323.64
V$E2F_Q4_01
(c3) Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NCSCGCSAAAN which matches annotation for E2F
TFDP1: transcription factor Dp-1
1.12361e-05137/1754323.578
REGULATION_OF_GENE_EXPRESSION
(c5) Genes annotated by the GO term GO:0010468. Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
1.13509e-05606/670155115.587
NEGATIVE_REGULATION_OF_TRANSCRIPTION
(c5) Genes annotated by the GO term GO:0016481. Any process that stops, prevents or reduces the frequency, rate or extent of transcription.
1.23861e-05169/1876540.963
GNF2_CENPE
(c4) Neighborhood of CENPE
1.54155e-0535/39155.876
V$COMP1_01
(c3) Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NVTNWTGATTGACNACAAVARRBN which matches annotation for MYOG: myogenin (myogenic factor 4)
1.56246e-0576/94197.981
V$E2F_Q6_01
(c3) Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NKCGCGCSAAAN which matches annotation for E2F
TFDP1: transcription factor Dp-1
1.74357e-05133/1714223.371